Syntheses and Pharmacological Activities of 2-Heterocyclic Substituted 4(3H)-Quinazolinone Derivatives
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چکیده
منابع مشابه
SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES
The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylatio...
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In the field of medicinal chemistry, Quinazolinone is a heterocyclic compound having unique place which has medicinal uses as Anticancer, antihypertensive, antihyperlipidemic, antitubercular, CNS depressant, antioxidant, analgesic, antibacterial, anti-inflammatory and antimalarial activity. Quinazolinone based drugs have broadened scope in the field of medicine and Research. Some quinazolinone ...
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Some new 4-phenyl-2,3-dihydro-6-(substitutedaminoethyl)10-iodo[1,2,4]-triazino[2,3-c]-quina-zolin-5-ones 6-14 have been synthesized from 4-(phenyl-2,3-dihydro-6-methyl-10-iodo [1,2,4]triazino[2,3-c]quinazolin-5-one 5 by introducing different heterocyclic nuclei. Compounds 5 and 6-14 have been screened for insecticidal, anti-fungal and antibacterial activities. Compound 4-phenyl-2, 3-dihydro-6-(...
متن کاملSYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l...
متن کاملSyntheses and activities of some bactobolin derivatives.
Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1972
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.20.2575